Open AccessSYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS
Author(s) -
Yulia Anita,
Muhammad Hanafi,
Amj Putra,
Surya Dwi Arifin,
Yoshinosuke Usuki,
Hideo Iio
Publication year - 2010
Publication title -
indonesian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.273
H-Index - 14
eISSN - 2460-1578
pISSN - 1411-9420
DOI - 10.22146/ijc.21701
Subject(s) - chemistry , streptomyces , leukemia , serine , secondary metabolite , ic50 , metabolite , yield (engineering) , stereochemistry , in vitro , microbiology and biotechnology , biochemistry , immunology , bacteria , phosphorylation , gene , genetics , materials science , metallurgy , biology
UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall yield was 87.10%. Keywords: UK-3A, Streptomyces sp. 517-02, Anticancer, P388 Murine Leukeumia cell