SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS | Zendy

Yulia Anita | Zendy; Muhammad Hanafi | Zendy; A.R. Budiman Putra | Zendy; Surya Dwi Arifin | Zendy; Yoshinosuke Usuki | Zendy; Hideo Iio | Zendy

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SYNTHESIS OF UK-3A ANALOGUE AND ASSAY ON P 388 MURINE LEUKEMIA CELLS

Author(s) -

Yulia Anita,

Muhammad Hanafi,

A.R. Budiman Putra,

Surya Dwi Arifin,

Yoshinosuke Usuki,

Hideo Iio

Publication year - 2010

Publication title -

indonesian journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.273

H-Index - 14

eISSN - 2460-1578

pISSN - 1411-9420

DOI - 10.22146/ijc.21701

Subject(s) - chemistry , streptomyces , leukemia , serine , secondary metabolite , ic50 , metabolite , yield (engineering) , stereochemistry , in vitro , microbiology and biotechnology , biochemistry , immunology , bacteria , phosphorylation , gene , genetics , materials science , metallurgy , biology

UK-3A is secondary metabolite of Streptomyces sp.517-02 which has IC50 38 µg/mL against P388 Murine Leukemia cells. An analogue of UK-3A was synthesized from L-methyl serine as the starting material by amidation and esterification. An analogue UK-3A was analyzed and identified by TLC, FT-IR, LC-MS and NMR spectrometer. It was found to have IC50 15.4µg/mL against the same Leukemia cells. The overall yield was 87.10%. Keywords: UK-3A, Streptomyces sp. 517-02, Anticancer, P388 Murine Leukeumia cell

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