Open AccessFormulation of Anti-Acne Gel of Moringa oleifera, L. Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis
Author(s) -
Dian Eka Ermawati,
Cahyarani Intan Ramadhani
Publication year - 2020
Publication title -
majalah farmaseutik
Language(s) - English
Resource type - Journals
eISSN - 2614-0063
pISSN - 1410-590X
DOI - 10.22146/farmaseutik.v16i2.50319
Subject(s) - moringa , maceration (sewage) , staphylococcus epidermidis , organoleptic , antibacterial activity , chemistry , flavonoid , food science , traditional medicine , bacteria , staphylococcus aureus , biology , medicine , biochemistry , materials science , antioxidant , composite material , genetics
Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which have antibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this study is to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula that can fulfills the physical properties of a good gel. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variation concentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity, adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positive control and polymer gel as negative control. The result showed that variations concentrations of ethanolic extract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion and spreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity, while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14 mm