Open AccessDistinct Mechanism between Arterial and Venous Thrombosis: Impact for Clinical Manifestations
Author(s) -
Muhamad Taufik Ismail
Publication year - 2019
Publication title -
aci (acta cardiologia indonesiana)
Language(s) - English
Resource type - Journals
eISSN - 2579-4345
pISSN - 2460-5700
DOI - 10.22146/aci.47683
Subject(s) - platelet , von willebrand factor , hemostasis , gpvi , thromboxane a2 , coagulation , adenosine diphosphate , medicine , platelet adhesiveness , thrombosis , tissue factor , tissue factor pathway inhibitor , thrombin , platelet activation , platelet membrane glycoprotein , chemistry , platelet aggregation
Hemostasis is a complex physiological process aiming to keep the integrity of a closed circulatory system after an occurrence of vessel wall injury. Hemostasis involving the role of circulating platelets and coagulation cascade.1 There are two major pathways that act independently to activate the platelet. The first pathway is mediated by collagen and the other by tissue factor. After intimal layer injury, platelets are recruited through the interaction between platelet’s surface glycoprotein (GPVI and GPIb/V/IX) with collagen and von Willebrand factor. This process results in adhesion of platelets in the site of injury. Further recruitment of platelets is achieved by secretion of aggregatory mediators such as thromboxane A2 and adenosine diphosphate.