Open AccessFeatures of the immune response formation to SARS-CoV-2 in patients who have recovered from COVID-19
Author(s) -
H.L. Kyseliova,
I.A. Anastasii,
O.B. Tonkovyd,
V.M. Isaiev,
Ю. В. Сидорова,
K.V. Voronova
Publication year - 2021
Publication title -
aktualʹnaâ infektologiâ
Language(s) - English
Resource type - Journals
eISSN - 2312-4148
pISSN - 2312-413X
DOI - 10.22141/2312-413x.9.3.2021.236225
Subject(s) - immune system , covid-19 , antibody , immunology , coronavirus , medicine , disease , virology , immunoassay , serology , antibody response , infectious disease (medical specialty)
This study was conducted to assess the presence of an immune response in staff of DILA Medical Laboratory who have recovered from COVID-19, to study the features of monitoring indicators in different clinical variants of the disease. The obtained results allowed analyzing various types of the immune response in patients with a new coronavirus disease. In staff who has recovered from COVID-19, an immune response study was performed by determining the presence of immunoglobulins M and G to various coronavirus target proteins by a semiquantitative method on a chemiluminescence immunoassay analyzer. The findings allowed us to assess not only the intensity of the immune response, but also the relationship with clinical manifestations, disease duration, age, which will be important for further comparative analysis with the immune response of vaccinated employees. The findings showed that most patients with COVID-19 produce protective antibodies, more often to the S-target, and also allowed determining the average duration of circulation of both immunoglobulin M and G antibodies.