Open AccessPleiotropic effects of ursodeoxycholic acid
Author(s) -
Yu.М. Stepanov,
А.В. Саленко
Publication year - 2021
Publication title -
gastroenterologìa/gastroenterologìâ
Language(s) - English
Resource type - Journals
eISSN - 2518-7880
pISSN - 2308-2097
DOI - 10.22141/2308-2097.55.2.2021.233637
Subject(s) - ursodeoxycholic acid , choleretic , g protein coupled bile acid receptor , farnesoid x receptor , bile acid , receptor , chemistry , signal transduction , pharmacology , biochemistry , nuclear receptor , biology , gene , transcription factor
The article summarizes the literature data on the expansion of the range of application of ursodeoxycholic acid due to its various mechanisms of action. Almost 50-year history of the study of its properties has proven choleretic, litholytic, antiapoptotic, anti-inflammatory, immunomodulatory, cytoprotective, antifibrotic and hypocholesterolemic effects. In addition to the well-known functions of bile acids, their role has been shown as signaling, endocrine molecules that regulate glucose, lipids, and energy metabolism through pathways mediated by the activation of the nuclear receptor of the farnesoid X receptor and the cell surface G protein-coupled receptor, TGR5. The variety of nosological forms in which this substance can be successfully used is substantiated.