Open AccessRenal Involvement at Cryoglobulinemic Vasculitis
Author(s) -
Т.Б. Бевзенко
Publication year - 2021
Publication title -
počki
Language(s) - English
Resource type - Journals
eISSN - 2307-1265
pISSN - 2307-1257
DOI - 10.22141/2307-1257.2.16.2016.72256
Subject(s) - medicine , pathology , nephrotic syndrome , lesion , kidney , glomerulonephritis , vasculitis , renal function , uric acid , nephropathy , disease , endocrinology , diabetes mellitus
The aim of the work was to evaluate the frequency and nature of renal lesion in patients with cryoglobulinemic vasculitis. According to clinical, laboratory and sonographic data renal damage is observed in 2/3 of the number of patients that is associated with the presence of the pathology of myocardium, joints, lungs and peripheral nervous system, with the severity of integrated extrarenal signs of the disease, and kidney failure is diagnosed in every second observation, nephrotic syndrome — in every sixth one. Morphological lesion of glomeruli, tubules and stroma of the kidneys resembles primary mesangioproliferative or mesangiocapillary glomerulonephritis with severe tubulointerstitial component. Renal function and the rate of progression of nephropathy influence the levels of high molecular weight proteins in the urine (fibronectin, b2-microglobulin) and nitrogen products (uric acid, nitrites), as well as physical and chemical surface features of urine.