Open AccessMicroglia and mast cells: new targets for the treatment of chronic pain
Author(s) -
V.I. Romanenko
Publication year - 2021
Publication title -
bolʹ, sustavy, pozvonočnik
Language(s) - English
Resource type - Journals
eISSN - 2307-1133
pISSN - 2224-1507
DOI - 10.22141/2224-1507.11.2.2021.236566
Subject(s) - palmitoylethanolamide , chronic pain , microglia , medicine , acute pain , intensive care medicine , inflammation , neuroscience , anesthesia , immunology , physical therapy , psychology , receptor , cannabinoid receptor , agonist
The article is devoted to the problem of effective management of chronic pain. A review of the known mechanisms of development and maintenance of chronic pain and possible methods of influence is given. One of the reasons for the lack of chronic pain treatment effectiveness in some patients is the use of treatment regimens with drugs acting exclusively on the targets located in the nerve structures. Today an important role of microglia and mast cells in the development and maintenance of chronic pain conditions is well acknowledged. A new class of drugs from the group of acylethanolamides is described. One of the representatives of this group is palmitoylethanolamide. This drug may modulate the activity of microglia and mast cells, thus increasing the pain threshold and the effectiveness of therapy. The use of palmitoylethanolamide in patients with chronic pain can increase the effectiveness of therapy.