Open AccessPeculiarities of Antithyroid Autoimmunity Indicators in Type 2 Diabetic Patients Depending on Leptin Level in Blood Serum and Their Dynamics as a Result of Sodium Selenite Treatment
Author(s) -
Н. О. Абрамова,
N.V. Pashkovska,
М.С. Березова
Publication year - 2021
Publication title -
mìžnarodnij endokrinologìčnij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2307-1427
pISSN - 2224-0721
DOI - 10.22141/2224-0721.1.65.2015.75872
Subject(s) - medicine , endocrinology , leptin , thyroglobulin , autoimmunity , type 1 diabetes , antibody , selenium , autoantibody , diabetes mellitus , thyroid peroxidase , thyroid , antibody titer , iodine , titer , immunology , disease , chemistry , obesity , organic chemistry
There were studied 46 patients with diabetes mellitus type 2 in order to identify the autoimmune processes directed against thyroid tissue and dependence of those changes on the level of leptin in blood serum. It was established that in patients with high leptin serum level antithyroid antibody titer increased. In order to adjust the levels of antithyroid antibodies sodium selenite was prescribed against the background of standard therapy. Statistically significant reduction in antibodies expression to thyroglobulin and thyroperoxidase after treatment with sodium selenite dosed 50 mg after a month has been found.