Open AccessCT Colonography in Preoperative Staging of Colon Cancer: Evaluation of FOxTROT Inclusion Criteria for Neoadjuvant Therapy
Author(s) -
Natally Horvat,
Aradhna Raj,
Sandy Liu,
Kristina A. Matkowskyj,
Andrea Knežević,
Marinela Capanu,
Jinru Shia,
Perry J. Pickhardt,
Marc J. Gollub
Publication year - 2019
Publication title -
american journal of roentgenology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.294
H-Index - 196
eISSN - 1546-3141
pISSN - 0361-803X
DOI - 10.2214/ajr.18.19928
Subject(s) - medicine , colorectal cancer , radiology , neoadjuvant therapy , panitumumab , response evaluation criteria in solid tumors , cohen's kappa , cancer , oncology , disease , progressive disease , cetuximab , breast cancer , machine learning , computer science
The purpose of the present study is to evaluate the diagnostic performance of and interreader agreement for CT colonography (CTC) in the local staging of colon cancer, with emphasis given to the FOxTROT (Fluoropyrimidine, Oxaliplatin, and Targeted-Receptor pre-Operative Therapy [Panitumumab]) trial inclusion criteria, which propose a new tailored treatment paradigm for colon cancer that uses neoadjuvant therapy for patients with a high-risk of locoregional disease as determined by imaging.