Open AccessOligopeptides as Biochemically Significant Molecules
Author(s) -
Yulia V. Boldyreva,
И. А. Лебедев,
E. V. Zakharchuk,
Javid F. Garaev,
Sofia V. Adamchuk,
Arthur M. Smilyanin
Publication year - 2021
Publication title -
vestnik uralʹskoj medicinskoj akademičeskoj nauki
Language(s) - English
Resource type - Journals
eISSN - 2500-0918
pISSN - 2073-9125
DOI - 10.22138/2500-0918-2021-18-2-138-146
Subject(s) - peptide , peptide bond , chemistry , amino acid , oligopeptide , molecule , stereochemistry , biochemistry , side chain , combinatorial chemistry , organic chemistry , polymer
Peptides are a class of organic substances consisting of two or more amino acid residues connected to each other by peptide bonds —C(O)NH—. Peptides were first mentioned in 1900 by the German organic chemist G. E. Fischer. He assumed that peptides consist of a chain of amino acids connected by a certain type of bond. In 1902, he was able to prove the presence of a peptide bond, and by 1905 he had developed a general method that allows synthesizing peptides in the laboratory. Friedrich Engels said the most succinctly about proteins: «Life is a way of existence of protein bodies...». It follows from this that if there are protein molecules, there is an organism’s life and, conversely, there are no proteins — the organism is not viable. Probably, this fact served as an incentive for further study of peptides. So, in the middle of the last century, an opinion appeared among scientists about a new class of chemically active substances-cytomedins (biologically active peptides, regulatory peptides, peptide bioregulators (PB)). These molecules will be discussed in this paper.