Open Access“You Can't Always Get What You Want” — Linearity as the Golden Ratio of Toxicology
Author(s) -
Aalt Bast,
Jaap C. Hanekamp
Publication year - 2014
Publication title -
dose-response
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.502
H-Index - 36
ISSN - 1559-3258
DOI - 10.2203/dose-response.13-032.hanekamp
Subject(s) - linearity , fibonacci number , golden ratio , simple (philosophy) , computer science , toxicology , mathematics , chemistry , philosophy , epistemology , biology , physics , discrete mathematics , geometry , quantum mechanics
Referring to the Golden Ratio (i.e. expressed in the Fibonacci sequence) in nature and art, we conclude that toxicology knows its own Golden Ration, namely linearity. The latter seems imposed on pharmaco-toxicological processes that in fact show far more complexity than simple linearity could hope to elucidate. Understanding physiological and pharmaco-toxicological processes as primarily linear is challenged in this contribution based on very straightforward principles and examples.