Open AccessPARENT CHILD RELATIONSHIP OF SECONDARY SCHOOL GIRL CHILDREN IN THE CONTEXT OF LOCALITY AND DIFFERENT SCHOOL BACKGROUND
Author(s) -
J. Shakila
Publication year - 2017
Publication title -
scholarly research journal for interdisciplinary studies
Language(s) - English
Resource type - Journals
eISSN - 2319-4766
pISSN - 2278-8808
DOI - 10.21922/srjis.v4i37.10661
Subject(s) - meloxicam , context (archaeology) , medicine , rheumatoid arthritis , in vivo , osteoarthritis , drug , biomedical engineering , pharmacology , pathology , biology , paleontology , alternative medicine , microbiology and biotechnology
Objective: The objective of this research work was to develop and evaluate the floating– pulsatile drug delivery system(FPDDS) of meloxicam intended for Chrono pharmacotherapy of rheumatoid arthritis. Methods: The system consistingof drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatilerelease, top cover buoyant layer was prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increaseretention of the oral dosage form in the stomach. Meloxicam is a COX-2 inhibitor used to treat joint diseases such asosteoarthritis and rheumatoid arthritis. For rheumatoid arthritis Chrono pharmacotherapy has been recommended toensure that the highest blood levels of the drug coincide with peak pain and stiffness. Result and discussion: Theprepared tablets were characterized and found to exhibit satisfactory physico-chemical characteristics. Hence, the mainobjective of present work is to formulate FPDDS of meloxicam in order to achieve drug release after pre-determined lagphase. Developed formulations were evaluated for in vitro drug release studies, water uptake and erosion studies, floatingbehaviour and in vivo radiology studies. Results showed that a certain lag time before drug release which was due to theerosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilicpolymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity andcomposition of buoyant layer. In vivo radiology studies point out the capability of the system of longer residence time ofthe tablets in the gastric region and releasing the drug after a programmed lag time. Conclusion: The optimizedformulation of the developed system provided a lag phase while showing the gastroretension followed by pulsatile drugrelease that would be beneficial for chronotherapy of rheumatoid arthritis and osteoarthritis.