Open AccessVeterinary perspective of the renal system in sepsis
Author(s) -
Beatriz Gasser,
Ricardo Andrés Ramírez Uscátegui,
Marjury Cristina Maronezi,
Ana Paula Rodrigues Simões,
Luiz Fernando Perez-Gomes,
Letícia Pavan,
Marcus Antônio Rossi Feliciano
Publication year - 2021
Publication title -
revista mvz córdoba/revista mvz cordoba
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.202
H-Index - 11
eISSN - 1909-0544
pISSN - 0122-0268
DOI - 10.21897/rmvz.2007
Subject(s) - sepsis , medicine , acute kidney injury , intensive care medicine , etiology , renal parenchyma , organ dysfunction , kidney , parenchyma , microcirculation , ultrasonography , radiology , pathology
This paper aims to review, discuss and define the factors associated with development of kidney injury in patients with sepsis, diagnosis alternatives, therapy and prevention, offering to the veterinarians an updated guide to improve the prognosis of sepsis patients. Sepsis is a clinical condition that leads to systemic complications and to multiple organ dysfunction syndrome (MODS), mainly due to poor tissue perfusion in humans and animals. Acute kidney injury (AKI) is considered the most frequent and lethal among organ complications secondary to sepsis, however the etiology of AKI in patients with sepsis is complex and multifactorial and not completely elucidated. Early diagnosis of AKI is difficult and consequently the treatment is not very successful, due to hemodynamic aspects. The ultrasonography seems to be a promising exam for early diagnosis of this lesion, especially with the advent of contrast-enhanced ultrasonography (CEUS) technique, which makes possible to detect microcirculation changes in the renal parenchyma, opening the door for a variety of physiological, clinical and therapeutic applications, however, studies proving CEUS accuracy for early detection of renal damage related to sepsis in humans and animals are still necessary.