Open AccessAnalysis of mdr1-1Δ mutation of MDR1 gene in the “Cimarron Uruguayo” dog
Author(s) -
Rosa Gagliardi B,
Cristina García G,
Silvia Llambí D,
María Arruga L
Publication year - 2013
Publication title -
revista mvz córdoba/revista mvz cordoba
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.202
H-Index - 11
eISSN - 1909-0544
pISSN - 0122-0268
DOI - 10.21897/rmvz.171
Subject(s) - breed , mutation , veterinary medicine , gene , genetics , medicine , biology
Objective. The aim of this paper is to analyze the frequency of the mdr1-1D mutation of the MDR1 gene in a dog sample of the Uruguayan Cimarron breed with the objective of increasing the knowledge of this breed’s genome. Materials and methods. Thirty-six animals of this breed were analyzed. The MDR1 gene region, which includes the location where the mutation would be present, was amplified by PCR. Results. The mutation was not detected in any of the analyzed Uruguayan Cimarron. Conclusions. The lack of described ivermectin intoxication cases in veterinary clinic in this breed is explained by the lack of the mutation object of this study. The sequence studied in Cimarron dogs is kept compared to other breeds, except Collies and related breeds (Border Collie, Bearded Collie, Old English sheepdog).