Open AccessThe role of diacereins in the treatment of osteoarthritis from the point of view of a new paradigm of pathogenesis
Author(s) -
Л. Н. Елисеева,
S. V. Kartashova
Publication year - 2021
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2021-2-4-79-84
Subject(s) - osteoarthritis , pathogenesis , disease , medicine , hyaline cartilage , hyaline , inflammation , articular cartilage , pathology , immunology , alternative medicine
Among the most common diseases of humanity in patients of the older age group, there is an articular pathology with degenerative changes in the hyaline cartilage, which significantly limits the functional activity of the locomotor apparatus. The rapid development of experimental scientific research in recent decades has made it possible to revise the concept of the pathogenesis of this process with confirmation of the leading role of inflammation in the development of functional and structural damage in this disease. These new data supported the change in the name of the disease from “osteoarthros” to “osteoarthritis” and justified the positive effects of individual drugs. The proposed lecture material discloses the topic of the modern understanding of the pathogenesis of osteoarthritis and the additional benefits of using drugs from the diacerein group due to their anti‑inflammatory and chondroprotective effect.