Open AccessNon-motor manifestations in patients with Parkinson's disease
Author(s) -
З. А. Гончарова,
M. A. Gelpey,
H. M. Mutalieva
Publication year - 2021
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2021-2-4-73-78
Subject(s) - depression (economics) , parkinson's disease , neuropsychology , movement disorders , anxiety , hospital anxiety and depression scale , disease , medicine , stage (stratigraphy) , montreal cognitive assessment , clinical significance , cognition , cognitive impairment , psychology , pediatrics , psychiatry , economics , paleontology , biology , macroeconomics
O bjec tiv e: to study the structure of NMS, their frequency and clinical significance at all stages of PD; to conduct a comparative analysis of the structure of NMS in PD, depending on the stage, form of the disease and gender characteristics of patients. Ma t erialand methods: examined 100 patients with PD, 31 patients as the control, and 11 patients as the comparison with Parkinson’s syndrome. The severity of movement disorders was assessed using the Hen and Yar scale. All patients with PD were also clinically assessed according to the UPDRS scale (parts II, III). Cognitive functions were assessed according to the Montreal CI scale (MOCA). The patients’ neuropsychological status was assessed using the Hospital Anxiety and Depression Scale (HADS). Results : vegetative disorders are a frequent manifestation of PD; they differ significantly depending on the gender of the patient and on the stage of the disease. In 20% of patients with PD clinically pronounced depression and severe cognitive impairment were revealed. Conclusion: non‑motor disorders are distinguished by a wide variety of manifestations and combinations, and their structure changes significantly from early to late stages of PD. The presence of NMS is an obligatory sign of PD. Although the structure of non‑motor manifestations of the disease is not specific, attention is drawn to the combination of more than ten different NMS in most patients, which does not occur with natural aging.