Open AccessFeatures of pharmacotherapy at elderly and senile patients
Author(s) -
А. В. Сафроненко,
Е. В. Ганцгорн,
В. А. Сафроненко,
И. И. Кузнецов,
Н. В. Сухорукова,
А. В. Криштопа,
Anna A. Osipova
Publication year - 2021
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2021-2-4-6-15
Subject(s) - polypharmacy , medicine , pharmacotherapy , pharmacodynamics , drug , drug reaction , pharmacokinetics , intensive care medicine , elderly people , quality of life (healthcare) , pharmacology , gerontology , nursing
The high risk of developing adverse drug reactions (ADRs) among elderly and senile patients is caused several reasons. Firstly, the age‑associated changes organs and system cause certain changes in pharmacodynamics and pharmacokinetics of drugs and, as a consequence, atypical ADRs. Secondly, polymorbidity, which is often present in this category of patients, causes the phenomenon of polypharmacy, thereby exacerbating the aspect of drug‑drug interactions – one of the risk factors for the development of ADRs. Finally, low level of knowledge in this area healthcare practitioners causes reason developing of «pharmacological cascades». The active applying of geriatric pharmacology in clinical practices gives the chance do better live the quality of life and the prediction of diseases for elderly and senile patients.