Open AccessHepatorenal syndrome: new insights about pathogenesis (part 1))
Author(s) -
Е. С. Крутиков,
A. N. Vostrikova,
М. С. Крутикова
Publication year - 2021
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2021-2-4-16-21
Subject(s) - hepatorenal syndrome , medicine , cirrhosis , intensive care medicine , pathogenesis , endothelial dysfunction , pathophysiology , bioinformatics , biology
An analysis of literature reviews, clinical studies, experimental research, clinical recommendations from pubmed / Medline and ELIBRARY databases on keywords for“liver cirrhosis”and“hepatorenal syndrome”was carried out. In accordance with modern studies, the idea of the pathophysiology of hepatorenal syndrome was revised in recent years, departing from the assumption that the development of this pathology is associated only with renal hypoperphusion due to the development of peripheral systemic arterial vasodilation. Today, the effect of cardiovascular, immune, endocrine systems, coagulation systems, hematological changes, endothelial dysfunction, reception of drugs and other factors for the development of renal dysfunction is studied.