Open AccessExperience of successful use of rituximab in treatment-resistant membranous nephropathy
Author(s) -
М. М. Батюшин,
N. A. Bronovitskaya,
Е. А. Синельник,
Н. Б. Бондаренко,
А. В. Разина,
К. Р. Богомолова
Publication year - 2020
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2020-1-3-91-94
Subject(s) - rituximab , membranous nephropathy , medicine , cyclophosphamide , clinical efficacy , nephropathy , proteinuria , chemotherapy , endocrinology , kidney , lymphoma , diabetes mellitus
The article presents as an introduction a short review on the problem of membranous nephropathy. A patient suffering from membranous nephropathy that is resistant to traditional therapy with glucocorticoids and cyclophosphane, as well as cyclosporine, was selected as a clinical case. The use of rituximab at a dose of 375 mg/m2 twice with a difference of one week led to the development of remission in the patient, normalization of clinical and laboratory parameters. No side effects of rituximab were detected.