Open AccessRelationship of gene polymorphism with the nature of target organ damage in patients with arterial hypertension
Author(s) -
N. V. Drobotya,
L. V. Arutyunyan,
А. А. Пироженко,
V. V. Kaltukova
Publication year - 2020
Publication title -
ûžno-rossijskij žurnal terapevtičeskoj praktiki
Language(s) - English
Resource type - Journals
ISSN - 2712-8156
DOI - 10.21886/2712-8156-2020-1-2-22-27
Subject(s) - arterial stiffness , medicine , gene polymorphism , polymorphism (computer science) , cardiology , left ventricular hypertrophy , pathogenesis , pathophysiology of hypertension , gene , blood pressure , genetics , biology , genotype
Objective : to assess the relationship of polymorphism of the main genes involved in the pathogenesis of arterial hypertension (AH) with indicators reflecting the state of target organs in the group of patients with arterial hypertension. Material and methods : we examined 100 patients with arterial hypertension who underwent standard diagnostic procedures, as well as molecular genetic research. Results : in patients with arterial hypertension statistically significant associations of AGTR2, GNB3, and NOS3 gene polymorphism with left ventricular hypertrophy, CYP11B2 and NOS3 gene polymorphism with left ventricular diastolic dysfunction, and NOS3 gene polymorphism with increased vascular wall stiffness were found (p < 0.05). Conclusions : the results of the study indicate that patients with arterial hypertension are a genetically heterogeneous group in terms of the relationship of specific gene polymorphism with indicators that characterize the state of target organs. The use of genetic approaches is promising for early screening of patients with arterial hypertension, belonging to the high-risk group, in order to ensure timely and effective organoprotection.