Open AccessAbnormal gut microbiota and impaired incretin effect as a cause of type 2 diabetes mellitus
Author(s) -
T. Yu. Demidova,
К. Г. Лобанова,
Т. Н. Короткова,
L. D. Kharchilava
Publication year - 2022
Publication title -
medicinskij vestnik ûga rossii
Language(s) - English
Resource type - Journals
eISSN - 2618-7876
pISSN - 2219-8075
DOI - 10.21886/2219-8075-2022-13-1-24-42
Subject(s) - incretin , type 2 diabetes mellitus , type 2 diabetes , insulin resistance , gut flora , diabetes mellitus , hormone , glucose homeostasis , medicine , endocrinology , secretion , bioinformatics , biology , immunology
It has now been established that the intestinal microbiota (CM) is one of the 11 links in the pathogenesis of type 2 diabetes mellitus (DM2). Th e fact is that when the composition of BM is disrupted and the concentration of its active metabolites changes, the processes of synthesis and secretion of incretin hormones are disrupted, the homeostasis of carbohydrates and fats in the body is disrupted, the processes of central regulation of appetite change, chronic infl ammation and insulin resistance of peripheral tissues develop. Th is review discusses possible ways of impairing the synthesis of incretin hormones and the incretin eff ect in patients with T2DM through the prism of BM and its active metabolites, and discusses possible ways of correcting the altered composition of BM with incretin drugs.A systematic literature search was carried out using the Scopus, PubMed, Web of Science databases.