Open AccessThe role of cytokines in bone remodeling and the pathogenesis of postmenopausal osteoporosis
Author(s) -
Г. А. Игнатенко,
И. Г. Немсадзе,
Е. Д. Мирович,
A. Churilov,
Э. А. Майлян,
А. Э. Глазков,
З С Румянцева
Publication year - 2020
Publication title -
medicinskij vestnik ûga rossii
Language(s) - English
Resource type - Journals
eISSN - 2618-7876
pISSN - 2219-8075
DOI - 10.21886/2219-8075-2020-11-2-6-18
Subject(s) - osteoimmunology , proinflammatory cytokine , osteoporosis , bone remodeling , pathogenesis , medicine , immune system , pathological , immunology , bioinformatics , inflammation , rankl , pathology , biology , receptor , activator (genetics)
About 20 years ago osteoimmunology was identified as new field of scientific knowledge. It studies patterns of immune and bone system interactions in normal and pathological conditions. The osteoimmunology achievements have fundamentally changed our ideas about the pathogenesis of human skeleton diseases, including osteoporosis. This review presents cytokines key role in physiological and pathological bone remodeling. The issues of interaction between cytokines, osteoblasts and osteoclasts are described in detail. The crucial role of proinflammatory cytokines increased production by immunocompetent cells in the postmenopausal osteoporosis development has been characterized. Pubmed, Scopus, Web of Science, MedLine, eLIBRARY.RU databases were used for systematic literature search.