Open AccessOVARIAN INFERTILITY FACTOR IN PATIENTS OF LATE REPRODUCTIVE AGE
Author(s) -
К. В. Урюпина,
И. И. Куценко,
Е. И. Кравцова,
П. А. Гаврюченко
Publication year - 2020
Publication title -
medicinskij vestnik ûga rossii
Language(s) - English
Resource type - Journals
eISSN - 2618-7876
pISSN - 2219-8075
DOI - 10.21886/2219-8075-2020-11-1-14-20
Subject(s) - fertility , infertility , follicular phase , ovarian reserve , assisted reproductive technology , medicine , reproductive technology , demography , gynecology , bioinformatics , biology , endocrinology , pregnancy , environmental health , population , genetics , lactation , sociology
Objective: in women over 35 years of age, there is a progressive and age-related decline in fertility, which is due to multiple consequences, including a decrease in follicular reserve. Cytokines play a role, mediating the interaction between oocytes and other cells. In addition, there is a change in the expression of mRNA of a number of genes, leading to a decrease in the ability to bear children. The goal is to highlight the problem of reducing fertility in women of older reproductive age. Materials and methods: medLine, Pubmed, RISC, etc. Results: analysis of literature data shows that fertility decline is determined by a combination of physiological, molecular and genetic factors that play an increasing role as we age. Conclusion: the development of modern technology can solve the problem of infertility in the vast majority of cases. However, the lack of effectiveness of assisted reproductive technologies (ART) for women over 35 years of age requires optimizing a care strategy for these women.