Open AccessEfficiency of complex therapy in patients with a- and hypogammaglobulinemia
Author(s) -
Д. И. Кролевец,
Л. П. Сизякина,
И. И. Андреева,
А. А. Яковлев,
О. А. Баштовая
Publication year - 2018
Publication title -
medicinskij vestnik ûga rossii
Language(s) - English
Resource type - Journals
eISSN - 2618-7876
pISSN - 2219-8075
DOI - 10.21886/2219-8075-2018-9-4-57-62
Subject(s) - hypogammaglobulinemia , antibody , immunity , medicine , immune system , antibody therapy , immunology , lymphocyte , humoral immunity , induction therapy , acquired immune system , cellular immunity , chemotherapy , monoclonal antibody
Objective: assessment of the eectiveness of the use of Polymuramil in complex with IVG therapy with patients with CVID and ХLA with insufcient replacement therapy. Materials and methods: there were 10 patients with insufcient eectiveness of IVIG replacement therapy, receiving complex IVIG therapy and immunomodulator Polymuramil at a dose of 200 μg / 0.5 ml No. 5 intramuscularly every other day, under study. Surface and intracellular markers of cells of the congenital and acquired immune response, serum immunoglobulins of class A, M, G - in the radial immunodiusion in the Mancini gel, the oxygen-dependent metabolic activity of neutrophils in NST-test were assessed with the help of ow cytometry, before and afer 3 months and a comparative analysis of the obtained data was conducted. Results: analysis of the data revealed a signifcant increase in markers of lymphocyte activation, which indicates the induction properties of the studied immunomodulator by increasing the activation potentials of the cellular link of adaptive immunity in patients with primary immunodefciency. Summary: in patients with a genetically mediated defect of the humoral immunity against the background of complex therapy with the use of Polymuramil, the activation of congenital and adaptive immunity is registered, which is confrmed, in addition to laboratory indexes, by a decrease in the frequency of exacerbations of chronic inammatory diseases.