Open AccessОценка жизнеспособности живых тканевых эквивалентов под действием импульсного тока со смещением
Author(s) -
Е.А. Шершунова,
И.Е. Ребров,
В.В. Мищенко,
А.И. Крюков,
Е.А. Воротеляк,
О.С. Роговая
Publication year - 2021
Publication title -
pisʹma v žurnal tehničeskoj fiziki
Language(s) - English
Resource type - Journals
eISSN - 1726-7471
pISSN - 0320-0116
DOI - 10.21883/pjtf.2021.13.51117.18606
Subject(s) - iontophoresis , penetration (warfare) , materials science , membrane , biomedical engineering , biological tissue , chemistry , engineering , biology , neuroscience , operations research , biochemistry
The paper deals with an electrophysical device for combined electroporative-iontophoretic effect on biological membranes. The experimental results on the influence of a pulsed current source with displacement on the viability of living tissue equivalents (LTE) cells are presented. There were obtained values of pulse electrophysical parameters providing preservation of LTE cell vitality. According to the obtained data we suggest that such electrophysical parameters can be used for drugs delivery through the equivalent of the round window membrane and for creation in the future a technology for the administration of drugs through biological barriers with the possibility of their penetration into the inner ear using pulsed electrical installations.