Open AccessЛазерная доставка и спектральное исследование хлоринсодержащего препарата для лечения онихомикоза при последовательном лазерном (λ=2819 nm) и фотодинамическом (λ=656± 10 nm) воздействии
Author(s) -
А.В. Беликов,
С.Н. Смирнов,
А.Д. Тавалинская
Publication year - 2021
Publication title -
optika i spektroskopiâ
Language(s) - English
Resource type - Journals
eISSN - 2782-6694
pISSN - 0030-4034
DOI - 10.21883/os.2021.06.50979.6-21
Subject(s) - photodynamic therapy , chlorin , laser , wavelength , materials science , radiation , irradiation , photochemistry , optoelectronics , chemistry , optics , physics , organic chemistry , nuclear physics
For the first time, the possibility of a dual-stage active laser delivery of a modern chlorin-containing photodynamic preparation under the nail plate for photodynamic therapy of onychomycosis was investigated and demonstrated. The extinction spectra of the photodynamic preparation Revixan (Areal Ltd., Russia) were investigated at different temperatures, as well as before and after exposure to Er:YLF-laser radiation with a wavelength of 2810 nm and photodynamic LED radiation with a wavelength of 656 ± 10 nm. It is shown that after heating and laser exposure, the amount of monomers in the chlorin-containing photodynamic preparation increases, and after photodynamic exposure decreases, which can affect the effectiveness of photodynamic therapy of onychomycosis.