Open AccessНовые возможности диагностики колоректального рака c помощью оптической системы детекции клеток на основе диэлектрофореза-=SUP=-*-=/SUP=-
Author(s) -
М. В. Кручинина,
Я.И. Прудникова,
Andrey Gromov,
В.М. Генералов,
К.В. Генералов,
В. Н. Кручинин,
Э.В. Кручинина,
Г.В. Шувалов,
И.Н. Яковина,
N. Bannova,
О.В. Минин,
И.В. Минин
Publication year - 2019
Publication title -
žurnal tehničeskoj fiziki
Language(s) - English
Resource type - Journals
eISSN - 1726-748X
pISSN - 0044-4642
DOI - 10.21883/os.2019.05.47666.15-19
Subject(s) - dielectrophoresis , rigidity (electromagnetism) , sensitivity (control systems) , colorectal cancer , viscoelasticity , amplitude , materials science , medicine , nuclear magnetic resonance , cancer , physics , nanotechnology , optics , composite material , electronic engineering , microfluidics , engineering
The possibilities of using electrical and viscoelastic parameters of erythrocytes in patients with colorectal cancer (CRC) of different stages were demonstrated using optical cell detection system based on the dielectrophoresis method. The deformation amplitude, portion of deformed cells, generalized viscosity, rigidity, equilibrium frequency position, and electrical conductivity were the most significant parameters for determining patients with CRC, as well as early and late stages, included in the created model of a riskometer for the disease diagnosis. The created diagnostic “panels” with a high diagnostic accuracy, sensitivity, and specificity allowed to one determine patients with CRC (specificity 0.91, sensitivity 0.96), as well as early and late stages of the disease (specificity 0.64, sensitivity 0.86).