Open AccessФизико-химические свойства и структура костного матрикса при смоделированном туберкулезном остите
Author(s) -
В.К. Крутько,
В.В. Казбанов,
О.Н. Мусская,
А.А. Гайдаш,
А.И. Кулак,
Н.М. Чекан,
М.С. Сердобинцев,
К.В. Скроцкая
Publication year - 2019
Publication title -
žurnal tehničeskoj fiziki
Language(s) - English
Resource type - Journals
eISSN - 1726-748X
pISSN - 0044-4642
DOI - 10.21883/jtf.2019.01.46977.131-18
Subject(s) - materials science , scanning electron microscope , bone matrix , chemistry , matrix (chemical analysis) , embrittlement , infrared spectroscopy , calcium , crystallography , composite material , metallurgy , organic chemistry , anatomy , medicine , cartilage
The physicochemical properties and structure of the bone matrix are studied in a case of simulated tuberculous osteitis without treatment and after a full course of specific antibacterial therapy. Using X-ray diffraction, infrared spectroscopy, thermal analysis, and scanning electron microscopy, we revealed that tuberculous osteitis causes fine disintegration of the bone matrix due to an increase in nonstoichiometric hydroxyapatite, formation of amorphous calcium phosphates, and a decrease of the organic phase, which is accompanied by embrittlement of the bone matrix. Excessive growth of carbonate-hydroxyapatite crystals of a mixed AB substitution type leads to excessive osteogenesis, accompanied by the uncontrolled growth of bone trabeculae. The presence of “liming” regions in the crystal lattice of hydroxyapatite increases the “binding” properties of the bone matrix in which mycobacteria are immobilized and removed in the composition of detritus.