Open AccessEfficacy of YAP1-gene Knockdown to Inhibit Alveolar-Epithelial-Cell Senescence and Alleviate Idiopathic Pulmonary Fibrosis (IPF)
Author(s) -
Wei Xu,
Weiwei Song,
Y U Wang,
Yumin Zan,
Mingjiong Zhang,
Min Li,
Qiqing Huang,
Weihong Zhao,
Yu Sun,
Robert M. Hoffman,
Jianzhong Wu
Publication year - 2021
Publication title -
cancer genomics and proteomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.234
H-Index - 40
eISSN - 1790-6245
pISSN - 1109-6535
DOI - 10.21873/cgp.20271
Subject(s) - idiopathic pulmonary fibrosis , yap1 , senescence , gene knockdown , pulmonary fibrosis , bleomycin , pathology , cancer research , biology , medicine , microbiology and biotechnology , fibrosis , lung , cell culture , gene , transcription factor , biochemistry , genetics , chemotherapy
The prevalence of idiopathic pulmonary fibrosis (IPF) increases with age and is associated with senescence of alveolar epithelial cells (AECs). AEC senescence in pulmonary cells mediates IPF. We herein aimed to determine if YAP1 gene knockdown, a member of the Hippo/YAP signal pathway, in the bleomycin (BLM)-induced mouse model of IPF, inhibits onset of senescence of AECs and alleviates IPF.