Open AccessValidation of the Optimum Timing of Assessment of Tumor Infiltrating Lymphocytes During Preoperative Chemotherapy for Breast Cancer
Author(s) -
Shinichiro Kashiwagi,
Yuka Asano,
Koji Takada,
Wataru Goto,
Rika Kouhashi,
Akimichi Yabumoto,
YUKIE TAUCHI,
Tamami Morisaki,
Kana Ogisawa,
Masatsune Shibutani,
Hiroaki Tanaka,
Masaichi Ohira
Publication year - 2022
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10127
Subject(s) - medicine , breast cancer , tumor infiltrating lymphocytes , oncology , hazard ratio , chemotherapy , receiver operating characteristic , pathological , multivariate analysis , biopsy , cancer , proportional hazards model , immunotherapy , confidence interval
Tumor microenvironment (TME) assessment is considered to play an important role in the prediction of prognosis and therapeutic response following breast cancer treatment. No consensus has been reached regarding evaluation methods despite reports on the utilization of tumor-infiltrating lymphocytes (TILs) for immune TME (iTME) monitoring. Optimum timing of iTME assessment has not yet been established.