Open AccessCirculating Cell-free DNA in Serum as a Marker for the Early Detection of Tumor Recurrence in Breast Cancer Patients
Author(s) -
Alakesh Bera,
Eric Russ,
John Karaian,
ADAM LANDA,
Surya Radhakrishnan,
Marappa G. Subramanian,
Matthew T. Hueman,
Harvey B. Pollard,
Hai Hu,
Craig D. Shriver,
Meera Srivastava
Publication year - 2022
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10106
Subject(s) - medicine , cell free fetal dna , breast cancer , oncology , biomarker , recurrent breast cancer , cancer , cancer recurrence , gastroenterology , biology , pregnancy , fetus , biochemistry , genetics , prenatal diagnosis
Circulating cell-free DNA (cfDNA) isolated from serum by noninvasive procedures can serve as a potential biomarker for the early detection of many cancers. The aim of this study was to implement a simple, yet effective quantitative method for measuring the cfDNA in serum and to investigate the relationship between cfDNA and the occurrence of recurrence in breast cancer (BrCa) patients.