Open AccessImpact of Hippocampal Avoidance – Prophylactic Cranial Irradiation in Small Cell Lung Cancer Patients
Author(s) -
Emmanouil Maragkoudakis,
Vasileios Kouloulias,
Maria Grenzelia,
ANDROMACHI KOUGIOUMTZOPOULOU,
ANNA ZYGOGIANNI,
VASILEIOS RAMFIDIS,
Andrianni Charpidou
Publication year - 2022
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10105
Subject(s) - prophylactic cranial irradiation , conventional pci , medicine , cochrane library , neurocognitive , lung cancer , hippocampal formation , chemoradiotherapy , radiation therapy , cognition , oncology , systematic review , intensive care medicine , neuroscience , meta analysis , medline , psychology , psychiatry , biology , myocardial infarction , biochemistry
Prophylactic cranial irradiation (PCI) is a well-established treatment of small cell lung cancer (SCLC) patients following response to initial chemoradiotherapy. The benefit of PCI does, however, come at the cost of cognitive decline. This has been attributed to radiation-induced toxicity at the hippocampus, a crucial anatomic area for cognition. Modern radiotherapy techniques allow dose reduction at the hippocampal region. In this review, the safety profile, effect on cognition, and changes on brain imaging modalities of hippocampal avoidance-PCI (HA-PCI) will be presented, aiming to identify a potential clinical rationale for SCLC patients.