Open AccessMonostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report
Author(s) -
EDELYN S. AZURIN,
Norio Yamamoto,
Katsuhiro Hayashi,
Akihiko Takeuchi,
Shinji Miwa,
Kentaro Igarashi,
Takashi Higuchi,
Hirotaka Yonezawa,
Sei Morinaga,
Yohei Asano,
Shiro Saito,
Hiroyuki Tsuchiya
Publication year - 2022
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10082
Subject(s) - rankl , fibrous dysplasia , osteoporosis , medicine , pathology , medullary cavity , concomitant , anatomy , activator (genetics) , receptor
This study aimed to present a rare case of fibrous dysplasia (FD) in a healthy young adult man with a concomitant osteoporotic vertebral compression fracture. FD is a benign lesion of the bone characterized by replacement of the medullary component with fibro-osseous tissue that contains abnormally arranged trabeculae of immature woven bone. Recently it has been reported that several bone tumors including FD express the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL). Therefore, we hypothesized that FD contributed to osteoporosis, linked by the RANK-RANKL pathway of osteoclastogenesis.