Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report | Zendy

Edelyn S Azurin | Zendy; Norio Yamamoto | Zendy; Katsuhiro Hayashi | Zendy; Akihiko Takeuchi | Zendy; Shinji Miwa | Zendy; Kentaro Igarashi | Zendy; Takashi Higuchi | Zendy; Hirotaka Yonezawa | Zendy; Sei Morinaga | Zendy; Yohei Asano | Zendy; Shiro Saito | Zendy; Hiroyuki Tsuchiya | Zendy

Open Access

Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report

Author(s) -

Edelyn S Azurin,

Norio Yamamoto,

Katsuhiro Hayashi,

Akihiko Takeuchi,

Shinji Miwa,

Kentaro Igarashi,

Takashi Higuchi,

Hirotaka Yonezawa,

Sei Morinaga,

Yohei Asano,

Shiro Saito,

Hiroyuki Tsuchiya

Publication year - 2022

Publication title -

cancer diagnosis and prognosis

Language(s) - English

Resource type - Journals

ISSN - 2732-7787

DOI - 10.21873/cdp.10082

Subject(s) - rankl , fibrous dysplasia , osteoporosis , medicine , pathology , medullary cavity , concomitant , anatomy , activator (genetics) , receptor

This study aimed to present a rare case of fibrous dysplasia (FD) in a healthy young adult man with a concomitant osteoporotic vertebral compression fracture. FD is a benign lesion of the bone characterized by replacement of the medullary component with fibro-osseous tissue that contains abnormally arranged trabeculae of immature woven bone. Recently it has been reported that several bone tumors including FD express the receptor activator of nuclear factor-kappa B (RANK) and its ligand (RANKL). Therefore, we hypothesized that FD contributed to osteoporosis, linked by the RANK-RANKL pathway of osteoclastogenesis.

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