Open AccessHyaluronic Acid May Be a Predictive Biomarker for Thrombocytopenia and Liver Dysfunction After Oxaliplatin-based Chemotherapy
Author(s) -
Takashi Miyata,
Yasuto Tomita,
Yuta Sannomiya,
Taigo Nagayama,
Ryosuke Kin,
Hisashi Nishiki,
Akifumi Hashimoto,
Yasuhiro Fujii,
Seiko Miura,
Daisuke Kaida,
Naohiko Nakamura,
Tomoharu Miyashita,
Hideto Fujita,
Nobuhiko Ueda,
Hiroyuki Takamura
Publication year - 2022
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10071
Subject(s) - oxaliplatin , medicine , capecitabine , colorectal cancer , chemotherapy , hyaluronic acid , gastroenterology , pathological , oncology , cancer , anatomy
Following oxaliplatin-based chemotherapy, approximately half of all colorectal cancer patients develop sinusoidal obstruction syndrome (SOS). SOS can be monitored by measuring splenic volume; however, obtaining this measurement is not a simple process. In this study, we evaluated changes in hyaluronic acid (HA) concentrations as a simpler marker of SOS.