Open AccessBladder Cancer-related microRNAs With In Vivo Efficacy in Preclinical Models
Author(s) -
Ulrich H. Weidle,
Fabian Birzele
Publication year - 2021
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10033
Subject(s) - microrna , druggability , bladder cancer , in vivo , epigenetics , cancer research , biology , cancer , autophagy , transcription factor , cell cycle , bioinformatics , medicine , apoptosis , computational biology , gene , genetics
Progressive and metastatic bladder cancer remain difficult to treat. In this review, we critique seven up-regulated and 25 down-regulated microRNAs in order to identify new therapeutic entities and corresponding targets. These microRNAs were selected with respect to their efficacy in bladder cancer-related preclinical in vivo models. MicroRNAs and related targets interfering with chemoresistance, cell-cycle, signaling, apoptosis, autophagy, transcription factor modulation, epigenetic modification and metabolism are described. In addition, we highlight microRNAs targeting transmembrane receptors and secreted factors. We discuss druggability issues for the identified targets.