Open AccessProteomic Analysis of the Non-genetic Response to Cisplatin in Lung Cancer Cells
Author(s) -
Cristine de Souza Dutra,
Carolina Lumertz Martello,
Nathan Araujo Cadore,
Henrique Bunselmeyer Ferreira,
Arnaldo Zaha,
Karina Mariante Monteiro
Publication year - 2021
Publication title -
cancer diagnosis and prognosis
Language(s) - English
Resource type - Journals
ISSN - 2732-7787
DOI - 10.21873/cdp.10032
Subject(s) - cisplatin , proteome , epigenetics , proteostasis , biology , a549 cell , cancer research , microbiology and biotechnology , chromatin remodeling , cell culture , bioinformatics , genetics , gene , chemotherapy
Drug resistance is the main cause of therapy failure in advanced lung cancer. Although non-genetic mechanisms play important roles in tumor chemoresistance, drug-induced epigenetic reprogramming is still poorly understood.