Open AccessWAIST-TO-HIP RATIO AS A REPRESENTATIVE INDICATOR FOR PRIMARY DETERMINATION OF RISK GROUP FOR NON-ALCOHOLIC FATTY LIVER DISEASE WOMEN WITH TYPE 2 DIABETES MELLITUS
Author(s) -
O. O. Plohotnichenko,
T. V. Tyzhnenko,
M. Y. Gorshunska,
Nataliya Krasova,
Zhanna Leshchenko,
A. I. Gladkih,
O. B. Gromakovska,
В. В. Полторак,
Нонна Кравчун
Publication year - 2019
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2019.3.09
Subject(s) - medicine , nonalcoholic fatty liver disease , waist–hip ratio , fatty liver , type 2 diabetes mellitus , diabetes mellitus , waist , risk factor , type 2 diabetes , logistic regression , body mass index , anthropometry , disease , gastroenterology , waist to height ratio , population , endocrinology , environmental health
In patients with type 2 diabetes mellitus complicated by nonalcoholic fatty liver disease (NAFLD) a pattern of biochemical and anthropometric measures, and their diagnostic value were studied. A significant increase in the waist-to-hip ratio (WHR) in the group of patients with NAFLD was found. In the course of further verification of the WHR diagnostic significance has been established that for men this indicator can not be considered as a risk factor for NAFLD. Using the logistic regression and Roc-analysis, a diagnostic model was developed for the allocation of risk groups for the development of NAFLD in women with type 2 diabetes under the WHR. Defined threshold value of the WHR — 0.93; sensitivity is 75%; specificity is 50%; PPV (positive prognostic value) — 44%, NPV (negative prognostic value) — 79%, аccuracy index — 58%. The calculation of the WHR is sufficiently informative, which makes it possible to use it in population surveys in obesity prevention programs, NAFLD, and type 2 diabetes mellitus. The model allows to form a risk group for NAFLD among women with type 2 diabetes using simple and affordable anthropometric indicator.