Open AccessPATHOGENETIC ASPECTS OF THE INTERMITTENT OF THE DEVELOPMENT OF THE POLYCYSTIC OVARY SYNDROME WITH PROLONGED COLD INFLUENCES IN THE EXPERIMENT
Author(s) -
Iryna Kuzmina,
M. V. Zhulikova
Publication year - 2018
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2018.4.05
Subject(s) - polycystic ovary , endocrinology , medicine , dehydroepiandrosterone , ovary , stimulation , leptin , hormone , estrous cycle , biology , obesity , androgen , insulin resistance
The aim of the research was to study the effect of intermittent cold effects (ICE) on the experimentally induced polycystic ovary syndrome (PCOS) in female rats to prevent the development of polycystic ovaries and elaboration the pathogenesis of its development. Simulation of PCOS was performed by subcutaneous injection of dehydroepiandrosterone acetate (DHEA) in rats for 25 days. A ICE was carried out by daily keeping the animals for 4 hours in a chamber in which the light regime and a temperature of + 4 °C were maintained. As a result of the experiments, it has been proved that after intracellular adaptive-compensatory reactions are activated in the ovarian tissue, which helps prevent the development of PCOS. In addition, ICE leads to an increase in the level of adipocytokines (adiponectin and leptin), which can indirectly affect the secretion of reproduction hormones and inhibit the development of cystic changes in the ovary. Stimulation of adaptive physiological reactions against the background of ICE blocks the development of signs of PCOS in rats.