Open AccessOXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS
Author(s) -
Nataliia Gorbenko,
Ivanova Ov,
Oleksii Borikov
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.3.10
Subject(s) - oxidative stress , insulin resistance , pathophysiology , pathogenesis , medicine , reactive oxygen species , diabetes mellitus , endothelium , oxidative damage , pharmacology , bioinformatics , endocrinology , biology , biochemistry
The review elucidates the role of oxidative stress in the pathogenesis of diabetic cardiovascularcomplications. It was analyzed the main reasons for excessive production of reactive oxygen speciesin the conditions of hyperglycemia and the basic mechanisms of their damaging effect on the morphological and functional state of the myocardium and endothelium. It was considered theperspective of natural antioxidants, such as flavonoids, for the prevention and treatment of diabeticmacroangiopathy. It was made a retrospective analysis of own researches devoted to the quercetin effect on the main factors of cardiometabolic risk at the insulin resistance syndrome