OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS | Zendy

Nataliia Gorbenko | Zendy; Olha Ivanova | Zendy; Oleksii Borikov | Zendy

Open Access

OXIDATIVE STRESS AS THE PATHOPHYSIOLOGICAL MECHANISMS IN THE DEVELOPMENT OF DIABETIC MACROANGIOPATHY AND PERSPECTIVES OF ITS CORRECTION BY FLAVONOIDS

Author(s) -

Nataliia Gorbenko,

Olha Ivanova,

Oleksii Borikov

Publication year - 2016

Publication title -

problems of endocrine pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.141

H-Index - 2

eISSN - 2518-1432

pISSN - 2227-4782

DOI - 10.21856/j-pep.2016.3.10

Subject(s) - oxidative stress , insulin resistance , pathophysiology , pathogenesis , medicine , reactive oxygen species , diabetes mellitus , endothelium , oxidative damage , pharmacology , bioinformatics , endocrinology , biology , biochemistry

The review elucidates the role of oxidative stress in the pathogenesis of diabetic cardiovascularcomplications. It was analyzed the main reasons for excessive production of reactive oxygen speciesin the conditions of hyperglycemia and the basic mechanisms of their damaging effect on the morphological and functional state of the myocardium and endothelium. It was considered theperspective of natural antioxidants, such as flavonoids, for the prevention and treatment of diabeticmacroangiopathy. It was made a retrospective analysis of own researches devoted to the quercetin effect on the main factors of cardiometabolic risk at the insulin resistance syndrome

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