THE ROLE OF AMPK AND MTOR IN THE DEVELOPMENT OF INSULIN RESISTANCE AND TYPE 2 DIABETES. THE MECHANISM OF METFORMIN ACTION (literature review) | Zendy

V.V. Pushkarev | Zendy; Л.К. Соколова | Zendy; М.D. Тronko | Zendy

Open Access

THE ROLE OF AMPK AND MTOR IN THE DEVELOPMENT OF INSULIN RESISTANCE AND TYPE 2 DIABETES. THE MECHANISM OF METFORMIN ACTION (literature review)

Author(s) -

V.V. Pushkarev,

Л.К. Соколова,

М.D. Тronko

Publication year - 2016

Publication title -

problems of endocrine pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.141

H-Index - 2

eISSN - 2518-1432

pISSN - 2227-4782

DOI - 10.21856/j-pep.2016.3.09

Subject(s) - metformin , insulin resistance , ampk , type 2 diabetes , mtorc1 , medicine , diabetes mellitus , pi3k/akt/mtor pathway , mechanism (biology) , mechanism of action , inflammation , insulin , obesity , endocrinology , pharmacology , biology , signal transduction , kinase , protein kinase a , microbiology and biotechnology , philosophy , biochemistry , epistemology , in vitro

It was analyzed the cellular and molecular links between chronic low-grade inflammation and caused by inflammation insulin resistance and type 2 diabetes. Particular emphasis is placed on the participation of AMPK and mTORC1 in the development of metabolic diseases caused by obesity. A detailed analysis of the biochemical mechanisms of action of the main drug used in the treatment of insulin resistance and type 2 diabetes — metformin.

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