Open AccessTHE ROLE OF AMPK AND MTOR IN THE DEVELOPMENT OF INSULIN RESISTANCE AND TYPE 2 DIABETES. THE MECHANISM OF METFORMIN ACTION (literature review)
Author(s) -
V.V. Pushkarev,
Л.К. Соколова,
М.D. Тronko
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.3.09
Subject(s) - metformin , insulin resistance , ampk , type 2 diabetes , mtorc1 , medicine , diabetes mellitus , pi3k/akt/mtor pathway , mechanism (biology) , mechanism of action , inflammation , insulin , obesity , endocrinology , pharmacology , biology , signal transduction , kinase , protein kinase a , microbiology and biotechnology , philosophy , biochemistry , epistemology , in vitro
It was analyzed the cellular and molecular links between chronic low-grade inflammation and caused by inflammation insulin resistance and type 2 diabetes. Particular emphasis is placed on the participation of AMPK and mTORC1 in the development of metabolic diseases caused by obesity. A detailed analysis of the biochemical mechanisms of action of the main drug used in the treatment of insulin resistance and type 2 diabetes — metformin.