Open AccessSTUDY OF THE INFLUENCE OF 6-(40 -IODOPHENYL)-2,3-DIHYDRO [2,1-B] THIAZOLE AT THYROID FUNCTION MALE WHITE RATS WITH EXPERIMENTAL AUTOIMMUNE THYROIDITIS
Author(s) -
N. G. Malova,
L. A. Sirotenko,
Irina Komarova,
E. S. Anikeeva,
A. V. Spiridonov,
A. N. Sova,
V. N. Vakula,
F. G. Yaremenko
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.3.05
Subject(s) - autoimmune thyroiditis , thyroglobulin , thyroid , medicine , thyroiditis , thyroid function , endocrinology , immunology
The study of new biologically active compound PL-308 with immunomodulating properties on the thyroid function in rats with experimental autoimmune thyroiditis. It was determined that the introduction of PL-308 reduces autoimmune aggression by lowering the level of antibodies to thyroglobulin, increases the number of all subpopulations of T-lymphocytes, in particular Tsuppressors. It was observed normalization of the functional state of the thyroid gland.