Open AccessALBUMINURIA AS A MARKER OF ENDOTHELIAL DYSFUNCTION AND EARLY PREDICTOR OF CARDIOVASCULAR COMPLICATION IN PATIENTS WITH DIABETES MELLITUS
Author(s) -
Н. А. Кравчун,
O. V. Zemlianitsyna,
I.V. Chernyavska,
Yu. I. Karachentsev
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.3.01
Subject(s) - albuminuria , medicine , renal function , diabetes mellitus , endothelial dysfunction , complication , kidney disease , endocrinology , type 2 diabetes , urology , microcirculation , albumin , cardiology , gastroenterology
The necessity to identify was grounded and assesses the dynamics of albuminuria and glomerular filtration rate in patients with type 1 and type 2 diabetes (as an early marker of endothelial dysfunction and a predictor of cardiovascular complication) on the background of pathogenetic therapy with glycosaminoglycans sulodexide was done. Clinically significant reduction in the excretion of both total protein and albumin in the urine was found. It indicates an improvement of microcirculation in the kidney along with an increase in glomerular filtration rate. The increase in the glomerular filtration rate is most pronounced in patients with type 2 diabetes with comorbid non-alcoholic fatty liver disease.