THE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME | Zendy

A. L. Zagayko | Zendy; Т. О. Брюханова | Zendy; A. I. Shkapo | Zendy

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THE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME

Author(s) -

A. L. Zagayko,

Т. О. Брюханова,

A. I. Shkapo

Publication year - 2016

Publication title -

problems of endocrine pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.141

H-Index - 2

eISSN - 2518-1432

pISSN - 2227-4782

DOI - 10.21856/j-pep.2016.2.09

Subject(s) - hormone , adiponectin , metabolic syndrome , insulin resistance , epigallocatechin gallate , quercetin , medicine , endocrinology , pathological , gallate , insulin , biology , polyphenol , pharmacology , obesity , biochemistry , antioxidant

It was established the experimental metabolic syndrome development in males of Syrian Golden hamsters on the background of the hypercaloric diet for 5 weeks. Pathological changes of metabolic links manifested by insulin resistance, a decrease in the content of adiponectin, hypercortisolaemia, leptinresistance and imbalance of sex hormones. The administration of the investigated compounds — quercetin and epigallocatechin gallate largely correct these changes. Epigallocatechin gallate had more expressive effect than quercetin.

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