Open AccessTHE EFFECT OF FLAVONOIDS ON HORMONAL BACKGROUND CHANGES IN EXPERIMENTAL METABOLIC SYNDROME
Author(s) -
A. L. Zagayko,
Т. О. Брюханова,
A. I. Shkapo
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.2.09
Subject(s) - hormone , adiponectin , metabolic syndrome , insulin resistance , epigallocatechin gallate , quercetin , medicine , endocrinology , pathological , gallate , insulin , biology , polyphenol , pharmacology , obesity , biochemistry , antioxidant
It was established the experimental metabolic syndrome development in males of Syrian Golden hamsters on the background of the hypercaloric diet for 5 weeks. Pathological changes of metabolic links manifested by insulin resistance, a decrease in the content of adiponectin, hypercortisolaemia, leptinresistance and imbalance of sex hormones. The administration of the investigated compounds — quercetin and epigallocatechin gallate largely correct these changes. Epigallocatechin gallate had more expressive effect than quercetin.