Open AccessIRON METABOLISM, ERYTHROPOIESIS AND IMMUNE INFLAMMATION IN ANEMIC PATIENTS WITH CHRONIC HEART FAILURE IN THE PRESENCE OF DIABETIC NEPHROPATHY
Author(s) -
Наталія Геннадіївна Риндіна,
Павло Григорович Кравчун,
Наталия Геннадьевна Рындина,
Павел Григорьевич Кравчун
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.2.06
Subject(s) - medicine , anemia , heart failure , inflammation , diabetic nephropathy , iron deficiency , erythropoiesis , hemoglobin , endocrinology , nephropathy , diabetes mellitus
The development of anemia in patients with chronic heart failure by the presence of diabeticnephropathy is characterized by erythropoietyc activity fall due to the low level of erythropoietinand functional iron deficiency, as a result of influence of pro-inflammatory cytokine level on hepcidinactivity, resulting in the disruption of the functional iron fund, deposited block of iron. The presenceof microalbuminaemia can be considered as a factor in formation of anemic syndrome due to loss oferythropoietin, transferrin, soluble transferring receptor as a part of protein’s pool in patients withchronic heart failure and diabetic nephropathy. The presence of anemia in patients with chronic heartfailure and diabetic nephropathy is associated with inadequate low central regulator of erythropoiesislevel in response to low hemoglobin concentrations on background of moderate decrease in glomerularfiltration rate.