TESTOSTERONE REPLACEMENT THERAPY IN MEN WITH TYPE 2 DIABETES AND FAILURE TESTOSTERONE SYNDROME

It was studied the influence of testosterone replacement therapy with prolonged action on thefunctional state of the pituitary-genital system, clinical symptoms of androgendeficiency in patientswith type 2 diabetes (DMt2) with androgendeficiency. The study involved 35 male patients with DMt2aged 39–72 years, duration of diabetes 2–14 years and total testosterone (T) levels < 10.4 nmol/l.For the purpose of replacement testosterone treatment was used (1000 mg) of the oil solution oftestosterone undecanoate. After 3 and 6 months after initiation of treatment there was a significantincrease in total testosterone concentration 14.6 ± 0.9 nmol/l and 17.0 ± 0.7 nmol/l, respectively vs8.3 ± 0.5 nmol/l before treatment (p < 0.05). Changes in the average levels of estradiol and lutropinduring treatment were not observed. No clinically significant side effects were not detected. Takinglong-acting testosterone undecanoate injection led to normalization of the total testosterone levelsand improve erectile function in men with type 2 diabetes and androgendeficiency.