Open AccessTHE IMPACT OF ENDOGENOUS AND EXOGENOUS ESTROGENS ON METABOLIC DISTURBANCES IN FEMALE RATS WITH TYPE 2 DIABETES
Author(s) -
Tetiana Kiprich,
Nataliia Gorbenko,
Oleksii Borikov,
Ivanova Ov
Publication year - 2016
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2016.1.06
Subject(s) - dyslipidemia , endocrinology , medicine , endogeny , type 2 diabetes , insulin resistance , estrogen , diabetes mellitus , obesity , basal (medicine)
It was investigated the impact of endogenous and exogenous estrogens on metabolic disturbances in female rats with type 2 diabetes. It was established that hypoestrogenic state increases insulin resistance, but doesn’t affect basal hyperglycemia, dyslipidemia and visceral obesity in diabetic female rats. Administration of compound PE0607 with selective estrogen-like activity as well as 17β-estradiol doesn’t influence hyperglycemia and insulin sensitivity, but suppresses dyslipidemia development. These results justify the perspectives of compound PE0607 use as a potential gender-specific agent for attenuation of cardiometabolic risk in type 2 diabetic women.