CARBOHYDRATE EXCHANGE IMPACT ON EXTRACELLULAR MATRIX IN PATIENTS WITH ACUTE MYOCARIAL INFARCTION AND TYPE 2 DIABETES MELLITUS

The study involved examination of 60 patients with acute myocardial infarction and type 2 diabetes mellitus, 40 patients with acute myocardial infarction and without type 2 diabetes mellitus and 20 substantially healthy subjects. The research allowed the authors to evaluate the effect of carbohydrate metabolism on extracellular matrix components in patients with acute myocardial infarction with the presence or absence of type 2 diabetes mellitus. The correlation relationship in patients with acute myocardial infarction and type 2 diabetes mellitus was found to be as follows: between matrix metalloproteinase-13 on the 1st–2nd day and glucose (r = 0.36; p < 0.05), glycosylated hemoglobin (r = 0.42; p < 0.05); tissue inhibitor of metalloproteinase-4 and glucose (r = 0.22; p < 0.05); tenascin C and glycosylated hemoglobin (r = –0.28; p < 0.05), glucose (r = –0.24; p < 0.05).