AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU | Zendy

Valentyna Dielievska | Zendy; I. P. Dunaeva | Zendy

Open Access

AUTOIMMUNE MECHANISMS OF CHRONIC HEART FAILURE PROGRESSION IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH CONCOMITANT TYPE 2 DIABETES MELLITU

Author(s) -

Valentyna Dielievska,

I. P. Dunaeva

Publication year - 2016

Publication title -

problems of endocrine pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.141

H-Index - 2

eISSN - 2518-1432

pISSN - 2227-4782

DOI - 10.21856/j-pep.2016.1.03

Subject(s) - medicine , heart failure , concomitant , autoantibody , cardiology , diabetes mellitus , pulmonary hypertension , ventricle , type 2 diabetes mellitus , copd , endocrinology , antibody , immunology

We examined whether autoantibodies against type IV collagen are associated with heart failure progression in arterial hypertension combined with chronic obstructive pulmonary disease with and without type 2 diabetes mellitus. Both patients with chronic heart failure in essential hypertension and chronic obstructive pulmonary disease and patients with concomitant type 2 diabetes mellitus showed higher levels of plasma type IV collagen autoantibodies in comparison to healthy controls. Type IV collagen antibodies correlated with dilation of the left ventricle and reduction of its contractility. Elevation of plasma type IV collagen autoantibodies is associated with progression of chronic heart failure in arterial hypertension combined and chronic obstructive pulmonary with and without type 2 diabetes mellitus.

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