Open AccessTHE ROLE OF COMPONENTS OF THE EXTRACELLULAR MATRIX IN THE DEVELOPMENT OF ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2 (literature review)
Author(s) -
M. Yu. Koteliukh,
Павло Григорович Кравчун
Publication year - 2021
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.4.13
Subject(s) - myocardial infarction , matrix metalloproteinase , medicine , diabetes mellitus , extracellular matrix , cardiology , type 2 diabetes mellitus , tenascin c , tenascin , disease , infarction , endocrinology , immunohistochemistry , chemistry , biochemistry , fibronectin
The article highlights the influence of matrix metalloproteinases, tissue inhibitors of metalloproteinases and tenascin C onto development and severity of the acute myocardial infarction in the patients with comorbide pathology. It was determined that the levels of matrix metalloproteinases were decreasing, and tissue inhibitors of metalloproteinases were raising in the patients with cardiovascular disease depending on the presence or absence of diabetes mellitus type 2. The attention was compelled to the ability of the extracellular matrix indicators to implement remodeling of the left ventricular myocardium in the patients with acute myocardial infarction and its complications. Here was exposed the changes in the parameters of the patients that have confirmed a promising study of their predicting properties at the development of cardiovascular complications in the patients with the acute myocardial infarction with concomitant diabetes mellitus type 2.