Open AccessCHANGES IN HISTOSTRUCTURE AND LEPTIN PRODUCING IN ADIPOSE TISSUE DURING LIGHT-INDUCED HYPOPINEALISM
Author(s) -
L. Yu. Sergiyenko,
Л. А. Бондаренко,
A. R. Gevorkyan,
N. N. Sotnik,
A. N. Cherevko,
T. V. Mishchenko
Publication year - 2015
Publication title -
problemi endokrinnoï patologìï
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.141
H-Index - 2
eISSN - 2518-1432
pISSN - 2227-4782
DOI - 10.21856/j-pep.2015.4.08
Subject(s) - adipose tissue , leptin , endocrinology , medicine , inflammation , hypoplasia , biology , adiponectin , obesity , insulin resistance
In the literature of recent years it was widely discussed the issue of violation of the light mode as a risk factor for the formation of obesity — one of the leading symptoms of metabolic syndrome and type 2 diabetes. However, until the real time, the effect of the long round-the-clock illumination of different duration on histological and leptinproducing activity of adipose tissue remains unclear. Studies of the dynamics of weight indicators, histological characteristics and the level of leptin in the blood plasma of rats subjected to long round-the-clock illumination, for 3, 5 and 10 months, led to the conclusion that, originally, animals subjected to long round-the-clock illumination observed an activation of hyperplastic processes in adipose tissue and increasing of its leptinsynthesizing activity. Long round-the-clock illumination as an inducer of expressed hypopinealizm is the cause hypoplasia of adipose tissue, a sharp drop of its cytokineproducing function and the development of its nonspecific inflammation.